Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

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Mooney, L and Skinner, M and Coker, S. J. and Currie, S. (2015) Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII. British Journal of Pharmacology. ISSN 1476-5381 (https://doi.org/10.1111/bph.13213)

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Abstract

Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.

ORCID iDs

Mooney, L, Skinner, M, Coker, S. J. and Currie, S. ORCID logoORCID: https://orcid.org/0000-0002-4237-4428;
CORE (COnnecting REpositories)