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Characterisation of a novel mouse liver aldo-keto reductase AKR7A5

Hinshelwood, A. and McGarvie, G. and Ellis, E. (2002) Characterisation of a novel mouse liver aldo-keto reductase AKR7A5. FEBS Letters, 523 (1-3). pp. 213-218. ISSN 0014-5793

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Abstract

We have characterised a novel aldo-keto reductase (AKR7A5) from mouse liver that is 78% identical to rat aflatoxin dialdehyde reductase AKR7A1 and 89% identical to human succinic semialdehyde (SSA) reductase AKR7A2. AKR7A5 can reduce 2-carboxybenzaldehyde (2-CBA) and SSA as well as a range of aldehyde and diketone substrates. Western blots show that it is expressed in liver, kidney, testis and brain, and at lower levels in skeletal muscle, spleen heart and lung. The protein is not inducible in the liver by dietary ethoxyquin. Immunodepletion of AKR7A5 from liver extracts shows that it is one of the major liver 2-CBA reductases but that it is not the main SSA reductase in this tissue.

Author(s):Hinshelwood, A., McGarvie, G. and Ellis, E.
Item type:Article
ID code:38116
Keywords:aldo-keto reductase, carbonyl metabolism, succinic semialdehyde, mouse liver , Pharmacy and materia medica, Biochemistry, Structural Biology, Cell Biology, Genetics, Molecular Biology, Biophysics
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Pharmaceutical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:02 Mar 2012 13:55
Last modified:03 Jan 2019 11:48
URI:https://strathprints.strath.ac.uk/id/eprint/38116
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