One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol
Kyne, Sara H and Percy, Jonathan M and Pullin, Robert D C and Redmond, Joanna M and Wilson, Peter G (2011) One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol. Organic and Biomolecular Chemistry, 9 (24). pp. 8328-8339. ISSN 1477-0520 (https://doi.org/10.1039/C1OB06372C)
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Abstract
Difluoroalkenylzinc reagents prepared from 1-(2’-methoxy-ethoxymethoxy)-2,2,2-trifluoroethane and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane at ice bath temperatures, underwent Negishi coupling with a range of aryl halides in a convenient one pot procedure. While significant differences between the enol acetal and carbamate reagents were revealed, the Negishi protocol compared very favourably with alternative coupling procedures in terms of overall yields from trifluoroethanol.
ORCID iDs
Kyne, Sara H, Percy, Jonathan M ORCID: https://orcid.org/0000-0001-8636-2704, Pullin, Robert D C, Redmond, Joanna M and Wilson, Peter G;-
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Item type: Article ID code: 35446 Dates: DateEvent2011Published15 September 2011Published OnlineSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 01 Nov 2011 16:24 Last modified: 18 Nov 2024 01:06 URI: https://strathprints.strath.ac.uk/id/eprint/35446