Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways
Dick, Lindsay and Dooley, Neil and Elliott, Moira A and Ford, Steven J and Gordon, Malcolm R and Halbert, Gavin W and Kerr, William J (2011) Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways. Journal of Pharmaceutical and Biomedical Analysis, 56 (3). pp. 633-636. ISSN 1873-264X (https://doi.org/10.1016/j.jpba.2011.06.025)
Full text not available in this repository.Request a copyAbstract
Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
ORCID iDs
Dick, Lindsay ORCID: https://orcid.org/0000-0002-8086-8701, Dooley, Neil, Elliott, Moira A ORCID: https://orcid.org/0000-0002-9964-5671, Ford, Steven J, Gordon, Malcolm R, Halbert, Gavin W and Kerr, William J ORCID: https://orcid.org/0000-0002-1332-785X;-
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Item type: Article ID code: 34327 Dates: DateEvent1 November 2011Published1 July 2011Published OnlineNotes: Copyright © 2011 Elsevier B.V. All rights reserved. Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 27 Jan 2012 13:19 Last modified: 11 Nov 2024 09:53 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/34327