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Open Access research which pushes advances in bionanotechnology

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SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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The neuropsychological effects of chronicmethylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder

Coghill, David, R and Rhodes, Sinéad M. and Matthews, Keith (2007) The neuropsychological effects of chronicmethylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder. Biological Psychiatry, 62. pp. 954-962. ISSN 0006-3223

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Abstract

The reported neuropsychological effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD) are in consistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. Wetherefore investigated the effects of chronic MPH administration on neuropsychological functioning. We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose andplacebo). Participants were 75 boys aged 7-15 years with ADHD. Neuropsychological performance was assessed with tests taken from theCambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. ChronicMPHimproved performance (p.001) on aspects of theGoNoGotask (p.02) and on threeCANTABtasks which togethercontributed to a 'recognition memory' component identified through principal components analysis (delayed matching to sample [DMtS],pattern and spatial recognition). There were no effects on other, high or low 'executive demand' tasks (p .05). GoNoGo performanceimprovements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS taskwas the sole baseline neuropsychological predictor of clinical response. Chronic MPH predominantly enhanced neuropsychological functioning on 'recognition memory' component tasks withmodest 'executive' demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPHin ADHD.