2-methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate

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Bhardwaj, Rajni M. and Florence, Alastair J. (2013) 2-methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate. Acta Crystallographica Section E: Crystallographic Communications, 69 (5). o752-o753. ISSN 2056-9890 (https://doi.org/10.1107/S1600536813009811)

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Abstract

In the title solvate, C17H20N4S· 2C3H8O, pairs of olanzapine molecules related by a centre of inversion stack along the a axis, forming columns, which are packed parallel to each other along the b axis, forming a sheet arrangement. The columns within these sheets are hydrogen bonded to each other through the propan-2-ol solvent molecules. The diazepine ring of the olanzapine exists in a puckered conformation with the thiophene and phenyl rings making a dihedral angle of 57.66 (7)° and the piperazine ring adopts a chair conformation with the methyl group in an equatorial position.

ORCID iDs

Bhardwaj, Rajni M. and Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;
CORE (COnnecting REpositories)