An expert consensus statement on biomarkers of ageing for use in intervention studies

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Perri, Giorgia and French, Chloe and Agostinis-Sobrinho, César and Anand, Atul and Antarianto, Radiana Dhewayani and Arai, Yasumichi and Baur, Joseph A and Cauli, Omar and Clivaz-Duc, Morgane and Colloca, Giuseppe and Demetriades, Constantinos and de Lucia, Chiara and Di Gessa, Giorgio and Diniz, Breno S and Dotchin, Catherine L and Eaglestone, Gillian and Elliott, Bradley T and Espeland, Mark A and Ferrucci, Luigi and Fisher, James and Grammatopoulos, Dimitris K and Hardiany, Novi S and Hassan-Smith, Zaki and Hastings, Waylon J and Jain, Swati and Joshi, Peter K and Katsila, Theodora and Kemp, Graham J and Khaiyat, Omid A and Lamming, Dudley W and Gallegos, Jose Lara and Madeo, Frank and Maier, Andrea B and Martin-Ruiz, Carmen and Martins, Ian J and Mathers, John C and Mattin, Lewis R and Merchant, Reshma A and Moskalev, Alexey and Neytchev, Ognian and Ni Lochlainn, Mary and Owen, Claire M and Phillips, Stuart M and Pratt, Jedd and Prokopidis, Konstantinos and Rattray, Nicholas J W and Rúa-Alonso, María and Schomburg, Lutz and Scott, David and Shyam, Sangeetha and Sillanpää, Elina and Tan, Michelle M C and Teh, Ruth and Tobin, Stephanie W and Vila-Chã, Carolina J and Vorluni, Luigi and Weber, Daniela and Welch, Ailsa and Wilson, Daisy and Wilson, Thomas and Zhao, Tongbiao and Philippou, Elena and Korolchuk, Viktor I and Shannon, Oliver M (2024) An expert consensus statement on biomarkers of ageing for use in intervention studies. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. ISSN 1758-535X (https://doi.org/10.1093/gerona/glae297)

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Abstract

Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method. A three-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of ageing. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of ageing. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (e.g., insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (e.g., high sensitivity c-reactive protein, interleukin-6), functional (e.g., muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (e.g., DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.

ORCID iDs

Perri, Giorgia, French, Chloe, Agostinis-Sobrinho, César, Anand, Atul, Antarianto, Radiana Dhewayani, Arai, Yasumichi, Baur, Joseph A, Cauli, Omar, Clivaz-Duc, Morgane, Colloca, Giuseppe, Demetriades, Constantinos, de Lucia, Chiara, Di Gessa, Giorgio, Diniz, Breno S, Dotchin, Catherine L, Eaglestone, Gillian, Elliott, Bradley T, Espeland, Mark A, Ferrucci, Luigi, Fisher, James, Grammatopoulos, Dimitris K, Hardiany, Novi S, Hassan-Smith, Zaki, Hastings, Waylon J, Jain, Swati, Joshi, Peter K, Katsila, Theodora, Kemp, Graham J, Khaiyat, Omid A, Lamming, Dudley W, Gallegos, Jose Lara, Madeo, Frank, Maier, Andrea B, Martin-Ruiz, Carmen, Martins, Ian J, Mathers, John C, Mattin, Lewis R, Merchant, Reshma A, Moskalev, Alexey, Neytchev, Ognian, Ni Lochlainn, Mary, Owen, Claire M, Phillips, Stuart M, Pratt, Jedd, Prokopidis, Konstantinos, Rattray, Nicholas J W ORCID logoORCID: https://orcid.org/0000-0002-3528-6905, Rúa-Alonso, María, Schomburg, Lutz, Scott, David, Shyam, Sangeetha, Sillanpää, Elina, Tan, Michelle M C, Teh, Ruth, Tobin, Stephanie W, Vila-Chã, Carolina J, Vorluni, Luigi, Weber, Daniela, Welch, Ailsa, Wilson, Daisy, Wilson, Thomas, Zhao, Tongbiao, Philippou, Elena, Korolchuk, Viktor I and Shannon, Oliver M;
CORE (COnnecting REpositories)