Impact of the COVID-19 pandemic on the utilisation and quality of antibiotic use in the Scottish primary care setting : a population-based segmented interrupted time series analysis

Al Balushi, Hayam and Kurdi, Amanj and Almutairi, Najla and Baker, Kirmanj Ismail and Amen, Karwan M and Karwi, Hardee and Seaton, Andrew and Godman, Brian (2024) Impact of the COVID-19 pandemic on the utilisation and quality of antibiotic use in the Scottish primary care setting : a population-based segmented interrupted time series analysis. Expert Review of Anti-infective Therapy. ISSN 1744-8336 (https://doi.org/10.1080/14787210.2024.2363485)

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Abstract

Inappropriate use of antibiotics is expected to increase during the COVID-19 pandemic, but there are limited data on COVID-19's long-term impact. We assessed the impact of COVID-19 on the quantity and quality of antibiotic use in Scotland. A segmented interrupted time series was applied to monthly dispensed antibiotics using prescription cost analysis data from March/2019 to March/2023. Antibiotic use was quantified using the number of items dispensed/1000 inhabitants (TIDs) and defined daily dose/1000 inhabitants/day (DIDs). The quality of antibiotic use was assessed using key quality indicators including the WHO AWaRe classification, proportion of broad-spectrum and "4C"-antibiotics. Overall, for all antibiotics, there was a non-significant increase in TIDs and DIDs before the first lockdown (March/2020) (β ), but a decline in the level immediately after the first (β ) and second lockdowns (β ) (November/2020), albeit non-significant. However, a significant increase in the time trend after the second lockdown (β ) for all antibiotic classes was observed. COVID-19 had no negative impact on AWaRe utilisation, with the proportion of all antibiotics from the Access group increasing from 76% in March/2019 to 90% in March/2023. The proportion of "4C" antibiotic reduced significantly after the second lockdown. Neither the utilisation nor the quality of total antibiotic use appeared to have been significantly affected by COVID-19.

ORCID iDs

Al Balushi, Hayam, Kurdi, Amanj ORCID logoORCID: https://orcid.org/0000-0001-5036-1988, Almutairi, Najla, Baker, Kirmanj Ismail, Amen, Karwan M, Karwi, Hardee, Seaton, Andrew and Godman, Brian;
CORE (COnnecting REpositories)