Directing hydrogen isotope exchange with aryl carboxylic acids

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Mudd, Richard J. and Reid, Marc and Paterson, Laura C. and Atzrodt, Jens and Derdau, Volker and Kerr, William J. (2024) Directing hydrogen isotope exchange with aryl carboxylic acids. Synlett, 35 (19). pp. 2201-2206. ISSN 0936-5214 (https://doi.org/10.1055/a-2239-6965)

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Abstract

A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

ORCID iDs

Mudd, Richard J. ORCID logoORCID: https://orcid.org/0000-0001-5786-3745, Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132, Paterson, Laura C., Atzrodt, Jens, Derdau, Volker and Kerr, William J. ORCID logoORCID: https://orcid.org/0000-0002-1332-785X;
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