Wet milling of mefenamic acid for seed generation : model-driven size reduction for maximizing yield

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Mehta, Bhavik and Brown, Cameron and Mitchell, Niall and Ottoboni, Sara (2022) Wet milling of mefenamic acid for seed generation : model-driven size reduction for maximizing yield. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

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Abstract

Introduction•Wet milling overcomes several common issues encountered with dry milling, including: - Undesired polymorphic and amorphous transformations - Loss of yield and process control - Increased energy cost • The aim of this work is to explore the region of attainable particle sizes based on the performance of a wet milling model, focusing on: - Development of a mechanistic model from initial small-scale experiments - Design space exploration to assess the quality attributes and suggest further experimental work with a view to make the model more robust

ORCID iDs

Mehta, Bhavik, Brown, Cameron ORCID logoORCID: https://orcid.org/0000-0001-7091-1721, Mitchell, Niall and Ottoboni, Sara ORCID logoORCID: https://orcid.org/0000-0002-2792-3011;
CORE (COnnecting REpositories)