Synthesis of water-soluble chiral DOTA lanthanide complexes with predominantly twisted square antiprism isomers and circularly polarized luminescence

Dai, Lixiong and Zhang, Junhui and Chen, Yuqing and MacKenzie, Lewis E. and Pal, Robert and Law, Ga-Lai (2019) Synthesis of water-soluble chiral DOTA lanthanide complexes with predominantly twisted square antiprism isomers and circularly polarized luminescence. Inorganic Chemistry, 58 (19). 12506–12510. ISSN 1520-510X (https://doi.org/10.1021/acs.inorgchem.9b01799)

[thumbnail of Dai-etal-IC-2019-Synthesis-of-water-soluble-chiral-DOTA-lanthanide-complexes]
Preview
 Text. Filename: Dai_etal_IC_2019_Synthesis_of_water_soluble_chiral_DOTA_lanthanide_complexes.pdf
Accepted Author Manuscript
Download (1MB)| Preview

Abstract

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ∼93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5– exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (ΔJ = 1) for [TbL3]– and 0.241 (ΔJ = 1) for [TbL4]5– in buffer solutions were recorded.

ORCID iDs

Dai, Lixiong, Zhang, Junhui, Chen, Yuqing, MacKenzie, Lewis E. ORCID logoORCID: https://orcid.org/0000-0002-8151-0525, Pal, Robert and Law, Ga-Lai;
CORE (COnnecting REpositories)