Towards clinical translation of 'second-generation' regenerative stroke therapies : hydrogels as game changers?

Totten, John D. and Alhadrami, Hani Abdullah and Jiffri, Essam Hussain and McMullen, Calum and Seib, F.Philipp and Carswell, Hilary V. O. (2021) Towards clinical translation of 'second-generation' regenerative stroke therapies : hydrogels as game changers? Trends in Biotechnology. ISSN 0167-7799 (https://doi.org/10.1016/j.tibtech.2021.10.009)

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Abstract

Stroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to "first-generation" stem cell-based therapies. Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. However no clinical trials have yet been successfully commissioned for these "second-generation" hydrogel-based therapies for chronic ischemic stroke regeneration. This review recommends a path forward to improve hydrogel technology for future clinical translation for stroke. Specifically, we suggest that a better understanding of human host stroke tissue-hydrogel interactions in addition to the effects of scaling up hydrogel volume to human-sized cavities would help guide translation of these second-generation regenerative stroke therapies.

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