Towards clinical translation of 'second-generation' regenerative stroke therapies : hydrogels as game changers?

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Totten, John D. and Alhadrami, Hani Abdullah and Jiffri, Essam Hussain and McMullen, Calum and Seib, F.Philipp and Carswell, Hilary V. O. (2021) Towards clinical translation of 'second-generation' regenerative stroke therapies : hydrogels as game changers? Trends in Biotechnology. ISSN 0167-7799 (https://doi.org/10.1016/j.tibtech.2021.10.009)

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Abstract

Stroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to "first-generation" stem cell-based therapies. Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. However no clinical trials have yet been successfully commissioned for these "second-generation" hydrogel-based therapies for chronic ischemic stroke regeneration. This review recommends a path forward to improve hydrogel technology for future clinical translation for stroke. Specifically, we suggest that a better understanding of human host stroke tissue-hydrogel interactions in addition to the effects of scaling up hydrogel volume to human-sized cavities would help guide translation of these second-generation regenerative stroke therapies.

ORCID iDs

Totten, John D. ORCID logoORCID: https://orcid.org/0000-0001-9665-1569, Alhadrami, Hani Abdullah, Jiffri, Essam Hussain, McMullen, Calum, Seib, F.Philipp ORCID logoORCID: https://orcid.org/0000-0002-1955-1975 and Carswell, Hilary V. O. ORCID logoORCID: https://orcid.org/0000-0002-0938-1212;
CORE (COnnecting REpositories)