Tablet disintegration performance : effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics

Markl, Daniel and Maclean, Natalie and Mann, James and Williams, Helen and Abbott, Alexander and Mead, Heather and Khadra, Ibrahim (2021) Tablet disintegration performance : effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics. International Journal of Pharmaceutics, 601. 120382. ISSN 1873-3476 (https://doi.org/10.1016/j.ijpharm.2021.120382)

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Abstract

The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and swelling behaviour of the tablet. This study demonstrates the use of the sessile drop method coupled with image processing and models to analyse the surface liquid absorption and swelling kinetics of four filler combinations (microcrystalline cellulose (MCC)/mannitol, MCC/lactose, MCC/dibasic calcium phosphate anhydrous (DCPA) and DCPA/lactose) with croscarmellose sodium as a disintegrant. Changes in the disintegration performance of these formulations were analysed by quantifying the effect of compression pressure and storage condition on characteristic liquid absorption and swelling parameters. The results indicate that the disintegration performance of the MCC/mannitol and MCC/lactose formulations are driven by the liquid absorption behaviour. For the MCC/DCPA formulation, both liquid absorption and swelling characteristics affect the disintegration time, whereas DCPA/lactose tablets is primarily controlled by swelling characteristics of the various excipients. The approach discussed in this study enables a rapid (< 1 min) assessment of characteristic properties that are related to tablet disintegration to inform the design of the formulation, process settings and storage conditions.

ORCID iDs

Markl, Daniel ORCID logoORCID: https://orcid.org/0000-0003-0411-733X, Maclean, Natalie ORCID logoORCID: https://orcid.org/0000-0003-0768-1673, Mann, James, Williams, Helen, Abbott, Alexander, Mead, Heather and Khadra, Ibrahim ORCID logoORCID: https://orcid.org/0000-0002-9846-1520;
CORE (COnnecting REpositories)