A traceless solid-phase synthesis of pteridines

Gibson, C.L. and La Rosa, S. and Suckling, C.J. (2003) A traceless solid-phase synthesis of pteridines. Tetrahedron Letters, 44 (6). pp. 1267-1270. ISSN 0040-4039 (https://doi.org/10.1016/S0040-4039(02)02782-X)

Full text not available in this repository.Request a copy

Abstract

The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

ORCID iDs

Gibson, C.L. ORCID logoORCID: https://orcid.org/0000-0003-4948-1266, La Rosa, S. and Suckling, C.J.;