The future of polar organometallic chemistry written in bio-based solvents and water

García-Álvarez, Joaquín and Hevia, Eva and Capriati, Vito (2018) The future of polar organometallic chemistry written in bio-based solvents and water. Chemistry - A European Journal. ISSN 0947-6539 (https://doi.org/10.1002/chem.201802873)

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Abstract

There is a strong imperative to reduce the release of volatile organic compounds (VOCs) into the environment, and many efforts are currently being made to replace conventional hazardous VOCs in favour of safe, green and bio-renewable reaction media that are not based on crude petroleum. Recent ground-breaking studies from a few laboratories worldwide have shown that both Grignard and (functionalised) organolithium reagents, traditionally handled under strict exclusion of air and humidity and in anhydrous VOCs, can smoothly promote both nucleophilic additions to unsaturated substrates and nucleophilic substitutions in water and other bio-based solvents (glycerol, deep eutectic solvents), competitively with protonolysis, at room temperature and under air. The chemistry of polar organometallics in the above protic media is a complex phenomenon influenced by several factors, and understanding its foundational character is surely stimulating in the perspective of the development of a sustainable organometallic chemistry.

  • Item type:Article
    ID code:65236
    Dates:
    Date
    Event
    19 June 2018
    Published
    19 June 2018
    Published Online
    15 June 2018
    Accepted
    Notes:This is the peer reviewed version of the following article: García-Álvarez, J, Hevia, E & Capriati, V 2018, 'The future of polar organometallic chemistry written in bio-based solvents and water' Chemistry - A European Journal. , which has been published in final form at https://doi.org/10.1002/chem.201802873. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:22 Aug 2018 13:46
    Last modified:25 Apr 2024 00:57
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/65236
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