Risk of hospitalisation with fever following MenB vaccination : self-controlled case series analysis

Murdoch, Heather and Wallace, Lynn and Bishop, Jennifer and Robertson, Chris and Claire Cameron, J (2017) Risk of hospitalisation with fever following MenB vaccination : self-controlled case series analysis. Archives of Disease in Childhood, 102 (10). pp. 894-898. ISSN 0003-9888 (https://doi.org/10.1136/archdischild-2017-313079)

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Abstract

OBJECTIVE: To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). DESIGN: 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled case series using linked routinely collected healthcare data, where the risk period was the 3 days immediately following receipt of a vaccine dose. PATIENTS: Children aged under 1 year in Scotland preintroduction and postintroduction of 4CMenB vaccine (pre-September 2014 to August 2015 and post-September 2015 to June 2016). MAIN OUTCOME MEASURES: Hospitalisations for fever attributable to 4CMenB vaccine. RESULTS: The postintroduction model showed an increased risk in the 3 days after dose 1 (relative incidence (RI), 10.78; 95% CI: 8.31 to 14.00) and dose 3 (RI, 9.80; 95% CI: 7.10 to 13.62), with a smaller increased risk after dose 2 (RI, 2.20; 95% CI: 1.27 to 3.82). The magnitude of these effects was greater than in the preintroduction model. The attributable fractions were 90.7%, 54.8% and 89.7%, equating to 162, 14 and 84 vaccine attributable cases per 100 000 doses, respectively.This is equivalent to 102 extra hospitalisations in Scotland annually, based on a birth cohort of 55 100 and extrapolated to 1430 across the UK based on a birth cohort of 777 165. CONCLUSION: There is an increased risk of hospital admission with fever within 3 days of the routine childhood immunisations at 8 and 16 weeks following introduction of 4CMenB vaccine. The results indicate that further understanding of the current use of prophylactic paracetamol is needed. Communication to parents and health professionals may also need to be re-examined, and guidance on the use of prophylactic paracetamol reinforced.

  • Item type:Article
    ID code:64933
    Dates:
    Date
    Event
    1 October 2017
    Published
    20 September 2017
    Published Online
    10 August 2017
    Accepted
    Notes:© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
    Subjects:Science > Microbiology > Immunology
    Medicine > Medicine (General)
    Department:Faculty of Science > Mathematics and Statistics
    Depositing user: Pure Administrator
    Date deposited:30 Jul 2018 10:42
    Last modified:14 Nov 2024 01:11
    URI:https://strathprints.strath.ac.uk/id/eprint/64933
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