Through barrier detection of ethanol using handheld Raman spectroscopy — Conventional Raman versus spatially offset Raman spectroscopy (SORS)

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Nicolson, Fay and Jamieson, Lauren E. and Mabbott, Samuel and Shand, Neil C. and Graham, Duncan and Faulds, Karen (2017) Through barrier detection of ethanol using handheld Raman spectroscopy — Conventional Raman versus spatially offset Raman spectroscopy (SORS). Journal of Raman Spectroscopy, 48 (12). pp. 1828-1838. ISSN 0377-0486 (https://doi.org/10.1002/jrs.5258)

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Abstract

Spatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from the point of laser excitation, scattered photons from deeper layers begin to dominate the acquired spectra, thus giving rise to through barrier detection. Here, we demonstrate the potential of conventional Raman (CR) and SORS for through barrier detection using handheld spectrometers. We report the collection of Raman signals from an ethanol solution through plastic at thicknesses of up to 21 mm using SORS in combination with multivariate analysis. SORS is compared to CR, where we also demonstrate impressive through barrier detection of ethanol at depths up to 9 mm. We also highlight the advantage of applying multivariate analysis for through barrier detection using CR or SORS, particularly when peaks with similar spectral features are present in both the barrier and analyte spectra. In addition, to the best of our knowledge, this is the first report of the assessment of the maximum level of through barrier detection using handheld CR and SORS instruments with a backscattering geometry.

ORCID iDs

Nicolson, Fay ORCID logoORCID: https://orcid.org/0000-0001-7154-9613, Jamieson, Lauren E. ORCID logoORCID: https://orcid.org/0000-0002-8996-2964, Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467, Shand, Neil C., Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105 and Faulds, Karen ORCID logoORCID: https://orcid.org/0000-0002-5567-7399;
  • Item type:Article
    ID code:63066
    Dates:
    Date
    Event
    20 December 2017
    Published
    28 September 2017
    Published Online
    22 August 2017
    Accepted
    Notes:This is the peer reviewed version of the following article: Nicolson, F., Jamieson, L. E., Mabbott, S., Shand, N. C., Graham, D., & Faulds, K. (2017). Through barrier detection of ethanol using handheld Raman spectroscopy—Conventional Raman versus spatially offset Raman spectroscopy (SORS). Journal of Raman Spectroscopy, 48(12), 1828-1838., which has been published in final form at https://doi.org/10.1002/jrs.5258. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Subjects:Science > Chemistry > Physical and theoretical chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    University of Strathclyde > University of Strathclyde
    Depositing user: Pure Administrator
    Date deposited:26 Jan 2018 11:37
    Last modified:15 Dec 2024 01:25
    URI:https://strathprints.strath.ac.uk/id/eprint/63066
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