C− H functionalisation for hydrogen isotope exchange

Atzrodt, Jens and Derdau, Volker and Kerr, William and Reid, Marc (2018) C− H functionalisation for hydrogen isotope exchange. Angewandte Chemie International Edition, 57 (12). pp. 3022-3047. ISSN 1433-7851 (https://doi.org/10.1002/anie.201708903)

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Abstract

The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demand a range of methods for their installation in an array of molecular architectures. In this Review, we describe recent advances in synthetic C−H functionalisation for hydrogen isotope exchange.