A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

Xu, Chao and Fyfe, James W.B. and Seath, Ciaran P. and Bennett, Steven H. and Watson, Allan J.B. (2017) A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system. Chemical Communications (London), 53. pp. 9139-9142. ISSN 0009-241X (https://doi.org/10.1039/C7CC05416E)

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Abstract

A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system is reported. An allylation/cross-coupling process of a haloaryl aldehyde, an aryl BPin, and an allyl BPin can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C–C bond formations without intervention. This process offers efficient access to an array of functionalised products including pharmaceutical and natural product scaffolds.

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• Item metadata

  Item type:	Article
  ID code:	61783
  Dates:	Date Event 26 July 2017 Published 26 July 2017 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	12 Sep 2017 14:25
  Last modified:	14 Jul 2024 01:32
  URI:	https://strathprints.strath.ac.uk/id/eprint/61783