A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system
Xu, Chao and Fyfe, James W.B. and Seath, Ciaran P. and Bennett, Steven H. and Watson, Allan J.B. (2017) A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system. Chemical Communications (London), 53. pp. 9139-9142. ISSN 0009-241X (https://doi.org/10.1039/C7CC05416E)
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Abstract
A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system is reported. An allylation/cross-coupling process of a haloaryl aldehyde, an aryl BPin, and an allyl BPin can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C–C bond formations without intervention. This process offers efficient access to an array of functionalised products including pharmaceutical and natural product scaffolds.
ORCID iDs
Xu, Chao, Fyfe, James W.B. ORCID: https://orcid.org/0000-0001-8501-9197, Seath, Ciaran P. ORCID: https://orcid.org/0000-0002-6774-128X, Bennett, Steven H. and Watson, Allan J.B.;-
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Item type: Article ID code: 61783 Dates: DateEvent26 July 2017Published26 July 2017AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 12 Sep 2017 14:25 Last modified: 11 Nov 2024 11:47 URI: https://strathprints.strath.ac.uk/id/eprint/61783