From emulsion to single-phase microfluidics : an integrated approach to culture and perfusion of multicellular spheroids

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McMillan, Kay S and Boyd, Marie and Zagnoni, Michele; (2016) From emulsion to single-phase microfluidics : an integrated approach to culture and perfusion of multicellular spheroids. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, IRL, pp. 399-400. ISBN 9781510834163

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Abstract

This study presents a novel microfluidic approach for developing large scale screening assays of anticancer compounds on 3D multicellular spheroids. We have developed a microfluidic device with associated protocols that combine the high-throughput characteristics of droplet microfluidics for spheroid formation and aggregation with those of single-phase microfluidics for substance exchange, long term culture and drug perfusion.

ORCID iDs

McMillan, Kay S ORCID logoORCID: https://orcid.org/0000-0001-8710-2496, Boyd, Marie ORCID logoORCID: https://orcid.org/0000-0003-4120-2218 and Zagnoni, Michele ORCID logoORCID: https://orcid.org/0000-0003-3198-9491;
CORE (COnnecting REpositories)