New avenues for drug delivery in Leishmania : using treatment of visceral leishmaniasis with amphotericin B as an exemplar

Carter, Katharine C. and Mullen, Alexander B.; Rivas, Luis and Gil, Carmen, eds. (2017) New avenues for drug delivery in Leishmania : using treatment of visceral leishmaniasis with amphotericin B as an exemplar. In: Drug Discovery in Leishmaniasis. Royal Society of Chemistry, Croydon, 224 - 234. ISBN 9781788012584

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Abstract

In this review the benefits of using a drug delivery system (DDS) to improve therapeutic outcome will be discussed using treatment of visceral leishmaniasis with amphotericin B (AMB), a poorly water soluble drug, as an exemplar. Progress in producing AMB formulations that can be given by intravenous, oral and pulmonary routes of administration is discussed.