Potential drug-drug interactions in paediatric outpatient prescriptions in Nigeria and implications for the future

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Oshikoya, Kazeem Adeola and Oreagba, Ibrahim Adekunle and Godman, Brian and Oguntayo, Fisayo Solomon and Fadare, Joseph and Orubu, Samuel and Massele, Amos and Senbanjo, Idowu Odunayo (2016) Potential drug-drug interactions in paediatric outpatient prescriptions in Nigeria and implications for the future. Expert Review of Clinical Pharmacology, 9 (11). pp. 1505-1515. ISSN 1751-2441 (https://doi.org/10.1080/17512433.2016.1232619)

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Abstract

BACKGROUND: Information regarding the incidence of drug-drug interactions (DDIs) and adverse drug events (ADEs) among paediatric patients in Nigeria is limited. METHODS: Prospective clinical audit among paediatric outpatients in four general hospitals in Nigeria over a 3-month period. Details of ADEs documented in case files was extracted. RESULTS: Among 1233 eligible patients, 208 (16.9%) received prescriptions with at least one potential DDI. Seven drug classes were implicated with antimalarial combination therapies predominating. Exposure mostly to a single potential DDI, commonly involved promethazine, artemether/lumefantrine, ciprofloxacin and artemether/lumefantrine. Exposure mostly to major and serious, and moderate and clinically significant, potential DDIs. Overall exposure similar across all age groups and across genders. A significant association was seen between severity of potential DDIs and age. Only 48 (23.1%) of these patients presented at follow-up clinics with only 15 reporting ADEs. CONCLUSION: There was exposure to potential DDIs in this population. However, potential DDIs were associated with only a few reported ADEs.

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