Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment

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Agnew, Lauren R. and Cruickshank, Dyanne L. and McGlone, Thomas and Wilson, Chick C. (2016) Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment. Chemical Communications, 52 (46). pp. 7368-7371. ISSN 1359-7345 (https://doi.org/10.1039/c6cc01032f)

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Abstract

A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

ORCID iDs

Agnew, Lauren R., Cruickshank, Dyanne L., McGlone, Thomas ORCID logoORCID: https://orcid.org/0000-0002-9897-1790 and Wilson, Chick C.;
CORE (COnnecting REpositories)