Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment
Agnew, Lauren R. and Cruickshank, Dyanne L. and McGlone, Thomas and Wilson, Chick C. (2016) Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment. Chemical Communications, 52 (46). pp. 7368-7371. ISSN 1359-7345 (https://doi.org/10.1039/c6cc01032f)
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Abstract
A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
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Item type: Article ID code: 56852 Dates: DateEvent11 June 2016Published19 February 2016Published Online19 February 2016AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 06 Jul 2016 11:10 Last modified: 14 Apr 2024 00:36 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/56852
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