Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications
Hester, Theodore J. and Dennison, Sarah R. and Baker, Matthew J. and Snape, Timothy J. (2015) Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications. Organic and Biomolecular Chemistry, 13 (29). pp. 8067-8070. ISSN 1477-0520 (https://doi.org/10.1039/c5ob00465a)
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Abstract
When adorned with n-octyl chains azobenzene is able to disrupt a variety of calcein-loaded phospholipid liposomes. The levels of lysis observed are dependent both on the lipid headgroup and the conformation of the azobenzene compound. In all cases studied, it has been shown that the cis-conformer is more membrane-interactive than the trans-conformer, suggesting that this class of molecule could be optimised for photo-dynamic therapy applications against infectious pathogens.
ORCID iDs
Hester, Theodore J., Dennison, Sarah R., Baker, Matthew J. ORCID: https://orcid.org/0000-0003-2362-8581 and Snape, Timothy J.;-
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Item type: Article ID code: 54536 Dates: DateEvent7 August 2015Published2 July 2015Published Online25 June 2015AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 12 Oct 2015 10:51 Last modified: 18 Oct 2024 00:24 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/54536