Hypertension linked to PDE3A activation

Houslay, Miles (2015) Hypertension linked to PDE3A activation. Nature Genetics, 47 (6). pp. 562-563. ISSN 1061-4036 (https://doi.org/10.1038/ng.3316)

Abstract

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

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• Item metadata

  Item type:	Article
  ID code:	54110
  Dates:	Date Event June 2015 Published 27 May 2015 Published Online
  Subjects:	Science > Natural history > Genetics Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	31 Aug 2015 08:14
  Last modified:	08 Apr 2024 22:29
  URI:	https://strathprints.strath.ac.uk/id/eprint/54110