Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

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Sin, Yuan Yan and Martin, Tamara P and Wills, Lauren and Currie, Susan and Baillie, George S (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signalling, 13. 16. (https://doi.org/10.1186/s12964-015-0094-x)

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Abstract

Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the molecular events that govern this event. We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective. This study aims to characterize the role of the complex in PKD1-mediated myocardial regulatory mechanisms that depend on PKD1 nuclear translocation.

ORCID iDs

Sin, Yuan Yan, Martin, Tamara P, Wills, Lauren, Currie, Susan ORCID logoORCID: https://orcid.org/0000-0002-4237-4428 and Baillie, George S;
CORE (COnnecting REpositories)