The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method

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Stones, G. and Argouarch, G. and Kennedy, A.R. and Sherrington, D.C. and Gibson, C.L. (2003) The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method. Organic and Biomolecular Chemistry, 1 (13). pp. 2357-2363. ISSN 1477-0520 (http://dx.doi.org/10.1039/b302887a)

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Abstract

Using L-valine methyl ester hydrochloride as starting material, the synthesis of ( 2S)- 2- isopropyl- 1,4,7- trimethyl-1,4,7- triazacyclononane is described. Various standard Richman - Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.

ORCID iDs

Stones, G., Argouarch, G., Kennedy, A.R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Sherrington, D.C. and Gibson, C.L. ORCID logoORCID: https://orcid.org/0000-0003-4948-1266;
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