The cardioprotective role of small heat shock protein 20

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Martin, Tamara and Currie, Susan and Baillie, George (2014) The cardioprotective role of small heat shock protein 20. Biochemical Society Transactions, 42 (2). pp. 270-273. ISSN 0300-5127 (https://doi.org/10.1042/BST20130272)

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Abstract

The small HSP (heat-shock protein) HSP20 is a molecular chaperone that is transiently up-regulated in response to cellular stress/damage. Although ubiquitously expressed in various tissues, it is most highly expressed in skeletal, cardiac and smooth muscle. Phosphorylation at Ser16 by PKA (cAMP-dependent protein kinase) is essential for HSP20 to confer its protective qualities. HSP20 and its phosphorylation have been implicated in a variety of pathophysiological processes, but most prominently cardiovascular disease. A wealth of knowledge of the importance of HSP20 in contractile function and cardioprotection has been gained over the last decade. The present mini-review highlights more recent findings illustrating the cardioprotective properties of HSP20 and its potential as a therapeutic agent.

ORCID iDs

Martin, Tamara, Currie, Susan ORCID logoORCID: https://orcid.org/0000-0002-4237-4428 and Baillie, George;
CORE (COnnecting REpositories)