Drugs from the seas - current status and microbiological implications
Proksch, P. and Edrada-Ebel, Ruangelie and Ebel, Rainer (2002) Drugs from the seas - current status and microbiological implications. Applied Microbiology and Biotechnology, 59 (2-3). pp. 125-134. ISSN 0175-7598 (https://doi.org/10.1007/s00253-002-1006-8)
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The oceans are the source of a large group of structurally unique natural products that are mainly accumulated in invertebrates such as sponges, tunicates, bryozoans, and molluscs. Several of these compounds (especially the tunicate metabolite ET-743) show pronounced pharmacological activities and are interesting candidates for new drugs primarily in the area of cancer treatment. Other compounds are currently being developed as an analgesic (ziconotide from the mollusc Conus magus) or to treat inflammation. Numerous natural products from marine invertebrates show striking structural similarities to known metabolites of microbial origin, suggesting that microorganisms (bacteria, microalgae) are at least involved in their biosynthesis or are in fact the true sources of these respective metabolites. This assumption is corroborated by several studies on natural products from sponges that proved these compounds to be localized in symbiotic bacteria or cyanobacteria. Recently, molecular methods have successfully been applied to study the microbial diversity in marine sponges and to gain evidence for an involvement of bacteria in the biosynthesis of the bryostatins in the bryozoan Bugula neritina.
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Item type: Article ID code: 48490 Dates: DateEventJuly 2002PublishedSubjects: Medicine > Pharmacy and materia medica
Science > MicrobiologyDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 11 Jun 2014 04:03 Last modified: 23 Dec 2024 01:12 URI: https://strathprints.strath.ac.uk/id/eprint/48490