Rapid syntheses of difluorinated dihydropyrans

Percy, Jonathan and Pintat, Stephane (2000) Rapid syntheses of difluorinated dihydropyrans. Chemical Communications, 2000 (7). pp. 607-608. ISSN 1359-7345 (https://doi.org/10.1039/b000006j)

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Abstract

A very short reaction sequence opens with metal-mediated addition of commercial bromodifluoropropene to aldehydes; allylation under phase transfer catalysed conditions sets the stage for a ring closing metathesis (RCM) in the presence of commercial Grubbs’ catalyst to afford potentially useful difluorinated dihydropyrans.