HFC-134a as a fluorinated building block : short syntheses of α-fluoroenones

Bainbridge, J Marie and Corr, Stuart and Kanai, Masatomi and Percy, Jonathan (2000) HFC-134a as a fluorinated building block : short syntheses of α-fluoroenones. Tetrahedron Letters, 41 (6). 971–974. ISSN 0040-4039 (https://doi.org/10.1016/S0040-4039(99)02184-X)

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Abstract

1,1,1,2-Tetrafluoroethane (HFC-134a) has been transformed into a range of -fluoroenones via a direct route. Dehydrofluorination/metallation allowed trifluorovinylsilanes to be prepared; these could be converted in situ, or isolated and treated further, with alkyllithium reagents to give difluorovinylsilanes. Fluoride-catalysed addition to aldehydes followed by acidic work-up allowed the isolation of a range of -fluoroenones in two- or three-pots.

ORCID iDs

Bainbridge, J Marie, Corr, Stuart, Kanai, Masatomi and Percy, Jonathan ORCID logoORCID: https://orcid.org/0000-0001-8636-2704;
CORE (COnnecting REpositories)