Rearrangement strategies for aryl-heteroatom bond formation

Porzelle, Achim and Tomkinson, Nicholas C. O. (2009) Rearrangement strategies for aryl-heteroatom bond formation. In: UNSPECIFIED.

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Abstract

A major interest in synthetic research is the controlled introduction and elaboration of new carbon-heteroatom bonds for the synthesis of arom. and heteroarom. products. Recently, C-H functionalization strategies have provided important contributions to the available methods. Although efficient and practical, the majority of these processes rely on activation with transition metals. The development of a metal-free methodol. to activate arom. rings would significantly augment the available methods and provide a valuable synthetic alternative. Within this talk we will present a versatile rearrangement strategy to access new aryl-heteroatom bonds through a formal metal-free C-H functionalization. The N-aryl hydroxylamine substrates for the rearrangement process (1) can easily be accessed from aryl halides via palladium and copper catalyzed coupling or from nitroarenes through a one-pot redn./protection sequence. Products accessed through this technol. provide fundamental building blocks for the prepn. of a variety of pharmacol. important heterocyclic scaffolds.

ORCID iDs

Porzelle, Achim and Tomkinson, Nicholas C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133;
  • Item type:Conference or Workshop Item(Other)
    ID code:34164
    Dates:
    Date
    Event
    2009
    Published
    Notes:CAPLUS AN 2009:985231(Conference; Meeting Abstract; Computer Optical Disk)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:11 Nov 2011 16:05
    Last modified:11 Nov 2024 16:31
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/34164
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