Synthesis of benzoxazolones from nitroarenes or aryl halides

Porzelle, Achim and Woodrow, Michael D and Tomkinson, Nicholas (2010) Synthesis of benzoxazolones from nitroarenes or aryl halides. Organic Letters, 12 (4). pp. 812-815. ISSN 1523-7060 (https://doi.org/10.1021/ol1902885j)

Abstract

A simple and effective method for the preparation of benzoxazolones from nitroarenes or aryl halides is described. Partial reduction of a nitro group in the presence of a chloroformate followed by a microwave assisted rearrangement/ring closure sequence provides a convenient and practical procedure to prepare this important pharmacophore. Rearrangement precursors were also accessed from aryl halides through transition-metal catalyzed coupling.

ORCID iDs

Tomkinson, Nicholas ORCID: https://orcid.org/0000-0002-5509-0133

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• Item metadata

  Item type:	Article
  ID code:	33074
  Dates:	Date Event 19 February 2010 Published
  Subjects:	Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	31 Aug 2011 14:08
  Last modified:	11 Nov 2024 09:49
  URI:	https://strathprints.strath.ac.uk/id/eprint/33074