Rearrangement strategy for the synthesis of 2-aminoanilines

Porzelle, Achim and Woodrow, Michael D and Tomkinson, Nicholas C. O. (2010) Rearrangement strategy for the synthesis of 2-aminoanilines. Organic Letters, 12 (7). pp. 1492-1495. ISSN 1523-7060 (https://doi.org/10.1021/ol100196a)

Abstract

Treatment of N-aryl hydroxylamines with trichloroacetonitrile in the presence of Imidazole provides a simple and effective method for the preparation of synthetically versatile 2-aminoanilines. Reactions proceed in DMF at 40 degrees C, providing the products in up to 86% isolated yield.

ORCID iDs

Tomkinson, Nicholas C. O. ORCID: https://orcid.org/0000-0002-5509-0133

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• Item metadata

  Item type:	Article
  ID code:	33072
  Dates:	Date Event 2 April 2010 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	30 Aug 2011 12:28
  Last modified:	11 Nov 2024 09:49
  URI:	https://strathprints.strath.ac.uk/id/eprint/33072