Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

Lizos, D.E. and Murphy, J.A. (2003) Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides. Organic and Biomolecular Chemistry, 1 (1). pp. 117-122. ISSN 1477-0520 (http://dx.doi.org/10.1039/b208114h)

Abstract

A brief, efficient and economical synthesis of the spiropyrrolidinyloxindoles, horsfiline and coerulescine, has been achieved, starting from itaconic acid and, respectively, p-anisidine or o-iodoaniline. Tandem radical cyclisation of iodoaryl alkenyl azides is the key step in both syntheses.

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• Item metadata

  Item type:	Article
  ID code:	23085
  Dates:	Date Event 7 January 2003 Published
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Strathprints Administrator
  Date deposited:	14 Jul 2010 11:07
  Last modified:	11 Nov 2024 09:29
  URI:	https://strathprints.strath.ac.uk/id/eprint/23085