Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction

Milliken, P.H. and Wadsworth, R.M. (2002) Superoxide and superoxide dismutase in pulmonary hypoxic vasoconstriction. Thorax, 57 (Supp.3). p. 75. ISSN 0040-6376 (https://doi.org/10.1136/thorax.57.suppl_3.iii48)

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Abstract

Superoxide is known to cause vascular damage and can consume protective NO that maintains a low pulmonary pressure. There is evidence suggesting that hypoxia upregulates NADH/NADPH oxidase and xanthine oxidase in the smooth muscle and endothelial cells of the pulmonary artery, increasing superoxide production. Superoxide dismutase (SOD) is widely distributed in the cells of the vasculature, destroying superoxide, however, the role of SOD in hypoxic vasoconstriction is unknown.1 Therefore, the effect of endogenous SOD inhibition and superoxide generation on hypoxic pulmonary vasoconstriction was investigated.

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• Item metadata

  Item type:	Article
  ID code:	22843
  Dates:	Date Event December 2002 Published
  Notes:	Non-variant with 22982 (text different).
  Subjects:	Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Strathprints Administrator
  Date deposited:	12 Jul 2010 10:16
  Last modified:	11 Nov 2024 09:29
  Related URLs:	Strathprints record
  URI:	https://strathprints.strath.ac.uk/id/eprint/22843