Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery

Kennedy, Charles and Syed, Nawazish-i-Husain (2008) Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery. Purinergic Signalling, 4 (S1). S201-S201. ISSN 1573-9538

Abstract

P2X receptors are Ca2+-permeable, ligand-gated cation channels, which are activated by ATP. In arteries, including the rat small pulmonary artery (SPA), they elicit vasoconstriction (Chootip et al., 2002), which is dependent upon extracellular Ca2+. The aim of this study was to determine the relative contributions of Ca2+ influx via the P2X receptor pore and voltage-dependent CaV1.2 (L-type) Ca2+ channels, and the role of Ca2+-induced Ca2+ release (CICR) in P2X receptormediated contractions of rat SPA.

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• Item metadata

  Item type:	Article
  ID code:	19503
  Dates:	Date Event May 2008 Published
  Notes:	Also published in: Fundamental & Clinical Pharmacology (2008), 22 (S2), p76.
  Subjects:	Medicine > Pharmacy and materia medica Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Strathprints Administrator
  Date deposited:	19 May 2010 10:34
  Last modified:	08 Apr 2024 17:37
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/19503