Plasmacytoid dendritic cells and antigen presentation to CD4+t cells

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Benson, R.A. and Hutchison, S. and Millington, O.R. and McInnes, I.B. and Garside, P. and Brewer, J.M. (2008) Plasmacytoid dendritic cells and antigen presentation to CD4+t cells. Immunology, 125 (s1). p. 102. ISSN 0019-2805 (http://dx.doi.org/10.1111/j.1365-2567.2008.02974.x)

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Abstract

The enigmatic antigen presenting role of plasmacytoid dendritic cells (pDCs) has generated considerable interest in recent years. More recently,their interactions with CD4+ T cells and subsequent regulation of pathology in models of autoimmune disease have made them interesting targets for biological intervention. Our studies in a novel murine model of rheumatoid arthritis (RA), demonstrate that pDCs act to limit the spontaneous induction of auto-reactive T cell responses and autoantibody production and can limit the severity of pathology.

ORCID iDs

Benson, R.A., Hutchison, S., Millington, O.R. ORCID logoORCID: https://orcid.org/0000-0002-3026-6550, McInnes, I.B., Garside, P. and Brewer, J.M.;
CORE (COnnecting REpositories)