Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Carlton, J.M. and Hirt, R.P. and Silva, J.C. and Delcher, A.L. and Schatz, M. and Zhao, Q. and Wortmam, J.R. and Bidwell, S.L. and Coombs, Graham H. (2007) Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315 (5809). pp. 207-212. ISSN 0036-8075 (http://dx.doi.org/10.1126/science.1132894)

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Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

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