Directing hydrogen isotope exchange with aryl carboxylic acids

Mudd, Richard J. and Reid, Marc and Paterson, Laura C. and Atzrodt, Jens and Derdau, Volker and Kerr, William J. (2024) Directing hydrogen isotope exchange with aryl carboxylic acids. Synlett. ISSN 0936-5214 (https://doi.org/10.1055/a-2239-6965)

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Abstract

A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

ORCID iDs

Mudd, Richard J. ORCID logoORCID: https://orcid.org/0000-0001-5786-3745, Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132, Paterson, Laura C., Atzrodt, Jens, Derdau, Volker and Kerr, William J.;
  • Item type:Article
    ID code:87924
    Dates:
    Date
    Event
    5 February 2024
    Published
    5 February 2024
    Published Online
    5 January 2024
    Accepted
    24 November 2023
    Submitted
    Notes:Publisher Copyright: © 2023 Georg Thieme Verlag. All rights reserved.
    Subjects:Science > Chemistry
    Department:University of Strathclyde > University of Strathclyde
    Depositing user: Pure Administrator
    Date deposited:26 Jan 2024 11:59
    Last modified:11 Nov 2024 14:12
    URI:https://strathprints.strath.ac.uk/id/eprint/87924
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