Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection
McCaughey, Laura C. and Ritchie, Neil D. and Douce, Gillian R. and Evans, Thomas J. and Walker, Daniel (2016) Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection. Scientific Reports, 6. 30201. ISSN 2045-2322 (https://doi.org/10.1038/srep30201)
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Abstract
Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intraspecies competition. The potency and targeted action of bacteriocins suggests that they could be developed into clinically useful antibiotics against highly drug resistant Gram-negative pathogens for which there are few therapeutic options. Here we show that Pseudomonas aeruginosa specific bacteriocins, known as pyocins, show strong efficacy in a murine model of P. aeruginosa lung infection, with the concentration of pyocin S5 required to afford protection from a lethal infection at least 100-fold lower than the most commonly used inhaled antibiotic tobramycin. Additionally, pyocins are stable in the lung, poorly immunogenic at high concentrations and efficacy is maintained in the presence of pyocin specific antibodies after repeated pyocin administration. Bacteriocin encoding genes are frequently found in microbial genomes and could therefore offer a ready supply of highly targeted and potent antibiotics active against problematic Gram-negative pathogens.
ORCID iDs
McCaughey, Laura C., Ritchie, Neil D., Douce, Gillian R., Evans, Thomas J. and Walker, Daniel ORCID: https://orcid.org/0000-0002-4206-2942;-
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Item type: Article ID code: 86400 Dates: DateEvent22 July 2016Published30 June 2016AcceptedSubjects: Science > Microbiology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 07 Aug 2023 13:17 Last modified: 03 Oct 2024 00:41 URI: https://strathprints.strath.ac.uk/id/eprint/86400