The toxicity of orthopaedic biomaterials chromium and nickel in rat hepatocytes

Gunaratnam, M. and Grant, M.H.; (2002) The toxicity of orthopaedic biomaterials chromium and nickel in rat hepatocytes. In: Transactions of the 28th Annual Meeting of the Society for Biomaterials. Society for Biomaterials. ISBN 8032087028

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Abstract

The toxicity of nickel, chromium (III) and (VI), vanadium and aluminium was compared in an immortalized neonatal rat osteoblast cell line using the MTT assay and a novel index of cytoxicity, alkaline phosphatase (ALP) activity.