Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

McKinnon, Zoe and Batchelor, Hannah and Khadra, Ibrahim and Halbert, Gavin (2022) Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid. British Journal of Pharmacy, 7 (2). ISSN 2058-8356 (https://doi.org/10.5920/bjpharm.1075)

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Abstract

Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on the solubility ofpoorly soluble drugs in vitro, simulated intestinal fluid (SIF) is usedin place of human intestinal fluid (HIF). However, typical SIF reflects averagecompositions of HIF rather than the full range of compositions previouslyreported. This study examines a new suite of SIF media (based on variabilityobserved in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.

ORCID iDs

McKinnon, Zoe, Batchelor, Hannah ORCID logoORCID: https://orcid.org/0000-0002-8729-9951, Khadra, Ibrahim ORCID logoORCID: https://orcid.org/0000-0002-9846-1520 and Halbert, Gavin;
CORE (COnnecting REpositories)