Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

McKinnon, Zoe and Batchelor, Hannah and Khadra, Ibrahim and Halbert, Gavin (2022) Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid. British Journal of Pharmacy, 7 (2). ISSN 2058-8356 (https://doi.org/10.5920/bjpharm.1075)

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Abstract

Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on the solubility ofpoorly soluble drugs in vitro, simulated intestinal fluid (SIF) is usedin place of human intestinal fluid (HIF). However, typical SIF reflects averagecompositions of HIF rather than the full range of compositions previouslyreported. This study examines a new suite of SIF media (based on variabilityobserved in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.

ORCID iDs

Batchelor, Hannah ORCID: https://orcid.org/0000-0002-8729-9951

Khadra, Ibrahim ORCID: https://orcid.org/0000-0002-9846-1520

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  Item type:	Article
  ID code:	83295
  Dates:	Date Event 2 November 2022 Published 15 July 2022 Accepted
  Subjects:	Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	22 Nov 2022 15:08
  Last modified:	11 Nov 2024 13:34
  URI:	https://strathprints.strath.ac.uk/id/eprint/83295