The concise guide to pharmacology 2021/22 : ion channels

Alexander, Stephen PH and Mathie, Alistair and Peters, John A and Veale, Emma L and Striessnig, Jörg and Kelly, Eamonn and Armstrong, Jane F and Faccenda, Elena and Harding, Simon D and Pawson, Adam J and Southan, Christopher and Davies, Jamie A and Aldrich, Richard W. and Attali, Bernard and Baggetta, Austin M and Becirovic, Elvir and Biel, Martin and Bill, Roslyn M. and Catterall, William A. and Conner, Alex C. and Davies, Paul and Delling, Markus and Virgilio, Francesco Di and Falzoni, Simonetta and Fenske, Stefanie and George, Chandy and Goldstein, Steve A. N. and Grissmer, Stephan and Ha, Kotdaji and Hammelmann, Verena and Hanukoglu, Israel and Jarvis, Mike and Jensen, Anders A. and Kaczmarek, Leonard K. and Kellenberger, Stephan and Kennedy, Charles and King, Brian and Kitchen, Philip and Lynch, Joseph W. and Perez‐Reyes, Edward and Plant, Leigh D. and Rash, Lachlan and Ren, Dejian and Salman, Mootaz M. and Sivilotti, Lucia G. and Smart, Trevor G. and Snutch, Terrance P. and Tian, Jinbin and Trimmer, James S. and Van den Eynde, Charlotte and Vriens, Joris and Wei, Aguan D. and Winn, Brenda T. and Wulff, Heike and Xu, Haoxing and Yue, Lixia and Zhang, Xiaoli and Zhu, Michael (2021) The concise guide to pharmacology 2021/22 : ion channels. British Journal of Pharmacology, 178 (S1). S157-S245. ISSN 1476-5381 (https://doi.org/10.1111/bph.15539)

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Abstract

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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