The concise guide to pharmacology 2021/22 : G protein‐coupled receptors

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Alexander, Stephen PH and Christopoulos, Arthur and Davenport, Anthony P and Kelly, Eamonn and Mathie, Alistair and Peters, John A and Veale, Emma L and Armstrong, Jane F and Faccenda, Elena and Harding, Simon D and Pawson, Adam J and Southan, Christopher and Davies, Jamie A and Abbracchio, Maria Pia and Alexander, Wayne and Al‐hosaini, Khaled and Bäck, Magnus and Barnes, Nicholas M. and Bathgate, Ross and Beaulieu, Jean‐Martin and Bernstein, Kenneth E. and Bettler, Bernhard and Birdsall, Nigel J.M. and Blaho, Victoria and Boulay, Francois and Bousquet, Corinne and Bräuner‐Osborne, Hans and Burnstock, Geoffrey and Caló, Girolamo and Castaño, Justo P. and Catt, Kevin J. and Ceruti, Stefania and Chazot, Paul and Chiang, Nan and Chini, Bice and Chun, Jerold and Cianciulli, Antonia and Civelli, Olivier and Clapp, Lucie H. and Couture, Réjean and Csaba, Zsolt and Dahlgren, Claes and Dent, Gordon and Singh, Khuraijam Dhanachandra and Douglas, Steven D. and Dournaud, Pascal and Eguchi, Satoru and Escher, Emanuel and Filardo, Edward J. and Fong, Tung and Fumagalli, Marta and Gainetdinov, Raul R and Gasparo, Marc de and Gerard, Craig and Gershengorn, Marvin and Gobeil, Fernand and Goodfriend, Theodore L. and Goudet, Cyril and Gregory, Karen J. and Gundlach, Andrew L. and Hamann, Jörg and Hanson, Julien and Hauger, Richard L. and Hay, Debbie L. and Heinemann, Akos and Hollenberg, Morley D. and Holliday, Nicholas D. and Horiuchi, Mastgugu and Hoyer, Daniel and Hunyady, László and Husain, Ahsan and IJzerman, Adriaan P. and Inagami, Tadashi and Jacobson, Kenneth A. and Jensen, Robert T. and Jockers, Ralf and Jonnalagadda, Deepa and Karnik, Sadashiva and Kaupmann, Klemens and Kemp, Jacqueline and Kennedy, Charles and Kihara, Yasuyuki and Kitazawa, Takio and Kozielewicz, Pawel and Kreienkamp, Hans‐Jürgen and Kukkonen, Jyrki P. and Langenhan, Tobias and Leach, Katie and Lecca, Davide and Lee, John D. and Leeman, Susan E. and Leprince, Jérôme and Li, Xaria X. and Williams, Tom Lloyd and Lolait, Stephen J. and Lupp, Amelie and Macrae, Robyn and Maguire, Janet and Mazella, Jean and McArdle, Craig A. and Melmed, Shlomo and Michel, Martin C. and Miller, Laurence J. and Mitolo, Vincenzo and Mouillac, Bernard and Müller, Christa E. and Murphy, Philip and Nahon, Jean‐Louis and Ngo, Tony and Norel, Xavier and Nyimanu, Duuamene and O’Carroll, Anne‐Marie and Offermanns, Stefan and Panaro, Maria Antonietta and Parmentier, Marc and Pertwee, Roger G. and Pin, Jean‐Philippe and Prossnitz, Eric R. and Quinn, Mark and Ramachandran, Rithwik and Ray, Manisha and Reinscheid, Rainer K. and Rondard, Philippe and Rovati, G. Enrico and Ruzza, Chiara and Sanger, Gareth J. and Schöneberg, Torsten and Schulte, Gunnar and Schulz, Stefan and Segaloff, Deborah L. and Serhan, Charles N. and Stoddart, Leigh A. and Sugimoto, Yukihiko and Summers, Roger and Tan, Valerie P. and Thal, David and Thomas, Walter (Wally) and Timmermans, Pieter B. M. W. M. and Tirupula, Kalyan and Tulipano, Giovanni and Unal, Hamiyet and Unger, Thomas and Valant, Celine and Vanderheyden, Patrick and Vaudry, David and Vaudry, Hubert and Vilardaga, Jean‐Pierre and Walker, Christopher S. and Wang, Ji Ming and Ward, Donald T. and Wester, Hans‐Jürgen and Willars, Gary B and Woodruff, Trent M. and Yao, Chengcan and Ye, Richard D. (2021) The concise guide to pharmacology 2021/22 : G protein‐coupled receptors. British Journal of Pharmacology, 178 (S1). S27-S156. ISSN 1476-5381 (https://doi.org/10.1111/bph.15538)

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Abstract

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

ORCID iDs

Alexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner‐Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P., Catt, Kevin J., Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H., Couture, Réjean, Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Singh, Khuraijam Dhanachandra, Douglas, Steven D., Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J., Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R, Gasparo, Marc de, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L., Goudet, Cyril, Gregory, Karen J., Gundlach, Andrew L., Hamann, Jörg, Hanson, Julien, Hauger, Richard L., Hay, Debbie L., Heinemann, Akos, Hollenberg, Morley D., Holliday, Nicholas D., Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, László, Husain, Ahsan, IJzerman, Adriaan P., Inagami, Tadashi, Jacobson, Kenneth A., Jensen, Robert T., Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles ORCID logoORCID: https://orcid.org/0000-0001-9661-5437, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans‐Jürgen, Kukkonen, Jyrki P., Langenhan, Tobias, Leach, Katie, Lecca, Davide, Lee, John D., Leeman, Susan E., Leprince, Jérôme, Li, Xaria X., Williams, Tom Lloyd, Lolait, Stephen J., Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Mazella, Jean, McArdle, Craig A., Melmed, Shlomo, Michel, Martin C., Miller, Laurence J., Mitolo, Vincenzo, Mouillac, Bernard, Müller, Christa E., Murphy, Philip, Nahon, Jean‐Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O’Carroll, Anne‐Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G., Pin, Jean‐Philippe, Prossnitz, Eric R., Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K., Rondard, Philippe, Rovati, G. Enrico, Ruzza, Chiara, Sanger, Gareth J., Schöneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L., Serhan, Charles N., Stoddart, Leigh A., Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P., Thal, David, Thomas, Walter (Wally), Timmermans, Pieter B. M. W. M., Tirupula, Kalyan, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean‐Pierre, Walker, Christopher S., Wang, Ji Ming, Ward, Donald T., Wester, Hans‐Jürgen, Willars, Gary B, Woodruff, Trent M., Yao, Chengcan and Ye, Richard D.;
CORE (COnnecting REpositories)