Morphological characterisation of solid pharmaceutical products using X-ray tomography

Doerr, Frederik and Brammer, Elanor and Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2017) Morphological characterisation of solid pharmaceutical products using X-ray tomography. In: Bruker micro-CT User Meeting, 2017-06-12 - 2017-06-15.

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Abstract

The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity. The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

ORCID iDs

Doerr, Frederik ORCID: https://orcid.org/0000-0001-5245-0503

Brammer, Elanor ORCID: https://orcid.org/0000-0002-9350-7761

Wood, Sarahjane ORCID: https://orcid.org/0000-0002-4285-0252

Florence, Alastair ORCID: https://orcid.org/0000-0002-9706-8364

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• Item metadata

  Item type:	Conference or Workshop Item(Speech)
  ID code:	73508
  Dates:	Date Event 14 June 2017 Published
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Strategic Research Themes > Advanced Manufacturing and Materials
  Depositing user:	Pure Administrator
  Date deposited:	10 Aug 2020 10:31
  Last modified:	11 Nov 2024 17:01
  URI:	https://strathprints.strath.ac.uk/id/eprint/73508