A traceless solid-phase synthesis of pteridines
Gibson, C.L. and La Rosa, S. and Suckling, C.J. (2003) A traceless solid-phase synthesis of pteridines. Tetrahedron Letters, 44 (6). pp. 1267-1270. ISSN 0040-4039 (https://doi.org/10.1016/S0040-4039(02)02782-X)
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The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.
ORCID iDs
Gibson, C.L.
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Item type: Article ID code: 723 Dates: DateEvent3 February 2003PublishedKeywords: pyrimidines, polystyrene, oxidative cleavage, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Unknown DepartmentDepositing user: Users 41 not found. Date deposited: 05 Apr 2006 Last modified: 01 Nov 2023 09:12 URI: https://strathprints.strath.ac.uk/id/eprint/723
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