A traceless solid-phase synthesis of pteridines

Gibson, C.L. and La Rosa, S. and Suckling, C.J. (2003) A traceless solid-phase synthesis of pteridines. Tetrahedron Letters, 44 (6). pp. 1267-1270. ISSN 0040-4039 (https://doi.org/10.1016/S0040-4039(02)02782-X)

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Abstract

The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

ORCID iDs

Gibson, C.L. ORCID logoORCID: https://orcid.org/0000-0003-4948-1266, La Rosa, S. and Suckling, C.J.;
  • Item type:Article
    ID code:723
    Dates:
    Date
    Event
    3 February 2003
    Published
    Keywords:pyrimidines, polystyrene, oxidative cleavage, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Unknown Department
    Depositing user:Users 41 not found.
    Date deposited:05 Apr 2006
    Last modified:01 Nov 2023 09:12
    URI:https://strathprints.strath.ac.uk/id/eprint/723
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