Alzheimer disease and Parkinson dementia distinguished by cognitive marker

Kozlova, Irina and Parra, Mario A. and Titova, Nataliya and Gantman, Maria and Della Sala, Sergio (2019) Alzheimer disease and Parkinson dementia distinguished by cognitive marker. Archives of Clinical Neuropsychology. ISSN 1873-5843 (In Press)

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    Background: Temporary Memory Binding (TMB) has been shown to be specifically affected by Alzheimer's Disease (AD) when it is assessed via free recall and titrating the task demands to equate baseline performance across patients. Methods: Patients with PD were subdivided into patients with and without cognitive impairment and compared with AD and amnestic MCI (aMCI) patients on their performance on the TMB. Results: The results show that only patients with AD dementia present with impaired TMB performance. ROC analyses showed that TMB holds high sensitivity and specificity for aMCI and AD relative to PD groups and healthy controls. Conclusion: TMB is sensitive to the neurodegenerative mechanisms leading to AD dementia but not to those underpinning PD dementia. As such, TMB task can aid the differential diagnosis of these common forms of dementia.