Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Mabbott, Samuel and Fernandes, Syrena C. and Schechinger, Monika and Cote, Gerard and Faulds, Karen and Mace, Charles R. and Graham, Duncan (2019) Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering. Analyst. ISSN 0003-2654 (https://doi.org/10.1039/C9AN01748H)

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Abstract

Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

ORCID iDs

Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467, Fernandes, Syrena C., Schechinger, Monika, Cote, Gerard, Faulds, Karen ORCID logoORCID: https://orcid.org/0000-0002-5567-7399, Mace, Charles R. and Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105;
  • Item type:Article
    ID code:70690
    Dates:
    Date
    Event
    28 November 2019
    Published
    28 November 2019
    Published Online
    28 November 2019
    Accepted
    Keywords:myocardial infarction, microfluidics, surface enhanced Raman scattering, Chemistry, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry, Electrochemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Technology and Innovation Centre > Bionanotechnology
    Depositing user: Pure Administrator
    Date deposited:05 Dec 2019 09:12
    Last modified:18 Sep 2022 04:44
    URI:https://strathprints.strath.ac.uk/id/eprint/70690
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