Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Mabbott, Samuel and Fernandes, Syrena C. and Schechinger, Monika and Cote, Gerard and Faulds, Karen and Mace, Charles R. and Graham, Duncan (2019) Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering. Analyst. ISSN 0003-2654

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    Abstract

    Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

    ORCID iDs

    Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467, Fernandes, Syrena C., Schechinger, Monika, Cote, Gerard, Faulds, Karen ORCID logoORCID: https://orcid.org/0000-0002-5567-7399, Mace, Charles R. and Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105;
    • Item type:Article
      ID code:70690
      Dates:
      Date
      Event
      28 November 2019
      Published
      28 November 2019
      Published Online
      28 November 2019
      Accepted
      Keywords:myocardial infarction, microfluidics, surface enhanced Raman scattering, Chemistry, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry, Electrochemistry
      Subjects:Science > Chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Technology and Innovation Centre > Bionanotechnology
      Depositing user: Pure Administrator
      Date deposited:05 Dec 2019 09:12
      Last modified:25 Jun 2021 03:21
      URI:https://strathprints.strath.ac.uk/id/eprint/70690
    CORE (COnnecting REpositories)