Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Mabbott, Samuel and Fernandes, Syrena C. and Schechinger, Monika and Cote, Gerard and Faulds, Karen and Mace, Charles R. and Graham, Duncan (2019) Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering. Analyst. ISSN 0003-2654

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    Abstract

    Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.