Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

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Mabbott, Samuel and Fernandes, Syrena C. and Schechinger, Monika and Cote, Gerard and Faulds, Karen and Mace, Charles R. and Graham, Duncan (2019) Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering. Analyst. ISSN 0003-2654 (https://doi.org/10.1039/C9AN01748H)

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Abstract

Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

ORCID iDs

Mabbott, Samuel ORCID logoORCID: https://orcid.org/0000-0003-4926-5467, Fernandes, Syrena C., Schechinger, Monika, Cote, Gerard, Faulds, Karen ORCID logoORCID: https://orcid.org/0000-0002-5567-7399, Mace, Charles R. and Graham, Duncan ORCID logoORCID: https://orcid.org/0000-0002-6079-2105;
CORE (COnnecting REpositories)